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Inhibitory effect of pomegranate extract powder on periodontitis in ra

구강생물학연구 2020년 44권 1호 p.37 ~ 44
김중화 ( Kim Joong-Hwa ) - Yedam Dental Hospital Dental Clinic

이경현 ( Lee Kyung-Hyun ) - Chosun University School of Dentistry Department of Periodontology
성세진 ( Sung Se-Jin ) - Chosun University School of Dentistry Department of Periodontology
강경민 ( Kang Kyung-Min ) - Chosun University School of Dentistry Department of Periodontology
임윤경 ( Lim Yun-Kyong ) - Chosun University School of Dentistry Korean Collection for Oral Microbiology and Department of Oral Biochemistry
국중기 ( Kook Joong-Ki ) - Chosun University School of Dentistry Department of Oral Biochemistry and Oral Biology Research Institute Korean Collection for Oral Microbiology
이원표 ( Lee Won-Pyo ) - Chosun University School of Dentistry Department of Periodontology
김병옥 ( Kim Byung-Ock ) - Chosun University School of Dentistry Department of Periodontology
유상준 ( Yu Sang-Joun ) - Chosun University School of Dentistry Department of Periodontology

Abstract


This study aimed to investigate the effect of pomegranate extract (PE) on the progression of periodontal disease in an experimental rat model of periodontitis. Periodontitis was induced in rats by placing a 5-0 black silk ligature and injecting a lipopolysaccharide of Porphyromonas gingivalis into the gingiva. Distilled water (DW) or PE solution was orally administered daily, and the animals were sacrificed after 3 weeks. Tissue specimens of the periodontitis model were analyzed using an enzyme-linked immunosorbent assay kit and by micro-computed tomography (CT) imaging. The expression levels of cyclo-oxygenase (COX)-1 and COX-2 were significantly reduced in ligation (Lig)+PE 22 μg/mL and Lig+PE 44 μg/mL groups, but there was no statistically significant difference in matrix metalloproteinase (MMP)-8 levels. Furthermore, micro-CT imaging demonstrated that alveolar bone resorption was inhibited in Lig+PE 22 μg/mL and Lig+PE 44 μg/mL groups compared with that in the Lig+DW group. These results demonstrate that PE has an inhibitory effect on the progression of alveolar bone loss caused by periodontal inflammation by reducing the expression levels of COX-1 and COX-2 in the process of periodontal disease.

키워드

Enzyme-linked immunosorbent assay; Periodontitis; Pomegranate; Prostaglandin-endoperoxide synthases; X-ray microtomography
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