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A rare case of chronic nonbacterial osteomyelitis of the mandible in a young adult male

구강생물학연구 2020년 44권 1호 p.51 ~ 60
김예슬, 최진혁, 정회인, Ku Jeong-Kui,
소속 상세정보
김예슬 ( Kim Ye-Sel ) - Yonsei University Department of Preventive Dentistry and Public Oral Health
최진혁 ( Choi Jin-Hyuk ) - Ministry of National Defense Criminal Investigation Command Scientific Investigations Laboratory Department of Forensic Medicine
정회인 ( Jung Hoi-In ) - Yonsei University Department of Preventive Dentistry and Public Oral Health
 ( Ku Jeong-Kui ) - Armed Forces Capital Hospital Department of Oral and Maxillofacial Surgery

Abstract


Chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis, is a rare disease of unknown etiology mainly affecting girls with a mean age of 10 years. The disease is characterized by nonbacterial osteolytic lesions and swelling of the adjacent soft tissues and has nonstandard treatment protocols. Unifocal CNO typically involves the mandible. Mandibular CNO is difficult to differentiate from bacterial osteomyelitis because of its similar radiographic profile and clinical symptoms. Therefore, magnetic resonance imaging (MRI) should be considered if infectious osteomyelitis has not been diagnosed by laboratory examination. Our patient was a young adult man with mandibular CNO presented with atypical bone fragments on MRI. Clinical symptoms improved within 3 days after surgical intervention to remove the fragments and treatment with a nonsteroidal anti-inflammatory drug (NSAID). NSAID therapy was discontinued at postoperative day 20, and the patient has experienced no recurrences at 5 months after surgery.

키워드

Chronic recurrent multifocal osteomyelitis; Magnetic resonance imaging; Mandible; Oral surgery

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