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소아청소년 갑상선암의 임상적 특징들: 단일 기관에서의 20년간의 연구

Clinical Characteristics of Pediatric & Adolescent Thyroid Cancer: A Single Institution Experience of 20 Years

대한두경부종양학회지 2020년 36권 2호 p.1 ~ 7
문기윤, 김광순, 배자성, 김정수,
소속 상세정보
문기윤 ( Moon Ki-Yoon ) - Catholic University College of Medicine Department of Surgery
김광순 ( Kim Kwang-Soon ) - Catholic University College of Medicine Department of Surgery
배자성 ( Bae Ja-Seong ) - Catholic University College of Medicine Department of Surgery
김정수 ( Kim Jeong-Soo ) - Catholic University College of Medicine Department of Surgery

Abstract


Background/Objectives: Pediatric & Adolescent thyroid cancer is a steadily increasing malignancy. We aimed to report our experience at a single tertiary institution and to evaluate the risk factors for recurrence in pediatric & adolescent patients with differentiated thyroid carcinoma (DTC).

Materials & Methods: The data of 42 pediatric & adolescent patients (aged ≤19 years) with DTC who underwent thyroidectomy at Seoul St. Mary’s Hospital (Seoul, Korea) between December 1997 and February 2019 were retrospectively reviewed. Clinicopathologic features and surgical outcomes were retrospectively analyzed through complete chart reviews.

Results: The mean age was 16.6 years. A total of 6 (14.3%) patients experienced recurrence after initial treatment. The recurrence rate was significantly different between total thyroidectomy (TT) and lobectomy groups(23.1% vs. 0%, p=0.038). However, no statistically significant differences were found in the recurrence rate according to lymph node ratio (LNR) of 0.4 (10.7% vs 21.4%; P=0.383). Multivariate analysis confirmed age (hazard ratio [HR], 0.443; P=0.008) and bilaterality (HR, 11.477; P=0.022) as significant risk factors for DFS.

Conclusion: Pediatric & Adolescent thyroid cancer is a rare malignancy and TT is recommended as the treatment of choice. However, lobectomy may be considered for Pediatric & Adolescent patients with age >16 years, tumor size <1 cm, and no bilateral disease.

키워드

Pediatric & adolescent; Thyroid cancer; Thyroidectomy; Disease-free survival

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