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Pathological, immunohistochemical, and bacteriological findings in dogs infected with Brucella canis

대한수의학회지 2020년 60권 1호 p.9 ~ 14
정지열 ( Jung Ji-Youl ) - Animal and Plant Quarantine Agency Animal Disease Diagnostic Division

윤순식 ( Yoon Soon-Seek ) - Animal and Plant Quarantine Agency Animal Disease Diagnostic Division
이승희 ( Lee Seung-Hee ) - Animal and Plant Quarantine Agency Animal Disease Diagnostic Division
박중원 ( Park Jung-Won ) - Animal and Plant Quarantine Agency Animal Disease Diagnostic Division
이진주 ( Lee Jin-Ju ) - Animal and Plant Quarantine Agency Division of Veterinary Bacterial Disease Division
허문 ( Her Moon ) - Animal and Plant Quarantine Agency Research Planning & Management Division, Animal and Plant Quarantine Agency
소병재 ( So Byung-Jae ) - Animal and Plant Quarantine Agency Animal Disease Diagnostic Division
김재훈 ( Kim Jae-Hoon ) - Jeju National University College of Veterinary Medicine and Veterinary Medical Research Institute

Abstract


This study describes pathological, immunohistochemical, and bacteriological findings in adult dogs and fetuses naturallyinfected with Brucella (B.) canis. A total of 42 dogs including 40 dogs and 2 aborted fetuses were examined. The most common grosslesions in infected dogs were swelling of lymph nodes and spleen. The testes showed marked swelling with multifocal to diffusereddish discoloration. The most significant histopathological lesions were observed in the placenta. Placental trophoblasts weremarkedly hypertrophied due to the accumulation of intra-cellular gram-negative bacteria. Lymphocytic inflammation of varyingseverity was observed in the reproductive organs such as male testis, epididymis, and prostate gland and female uterus. Strongimmunolabelling was observed in the cytoplasm of most trophoblasts in the placental tissues using immunohistochemistry. However,immunohistochemical staining did not demonstrate any organisms in other organs of dogs and fetuses. B. canis isolates were mostfrequently obtained from the whole blood (82.5%) and superficial inguinal lymph node (77.5%) in both sexes. In addition, theisolation rate was higher in male genital organs than in those of females. Hence, management of male dogs is most important becauseinfected dogs can play a role as carriers.

키워드

bacteriology; Brucella canis; immunohistochemistry; pathology
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