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Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis

대한수의학회지 2020년 60권 1호 p.19 ~ 24
이강일 ( Lee Kang-Il ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Internal Medicine

윤태식 ( Yun Tae-Sik ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Internal Medicine
함준상 ( Ham Jun-Sang ) - Rural Development Administration National Institute of Animal Science
이완규 ( Lee Wan-Kyu ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Bacteriology and Infectious Diseases
강지헌 ( Kang Ji-Houn ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Internal Medicine
양만표 ( Yang Mhan-Pyo ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Internal Medicine
강병택 ( Kang Byeong-Teck ) - Chungbuk National University College of Veterinary Medicine Laboratory of Veterinary Internal Medicine

Abstract


This study assessed the effects of probiotics in canine atopic dermatitis (AD). We enrolled 11 client-owned dogs with ADand randomly allocated them to two groups. The probiotics group (n = 7) was prescribed with Bifidobacterium longum while thecontrol group (n = 4) received a placebo powder once a day for 12 weeks. In both groups, the degree of skin lesions was evaluatedbased on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4. We also measured the transepidermal water loss(TEWL). We assessed pruritus severity using the pruritus visual analog scale (PVAS). Alteration of consumed drug doses wasconverted into medication scores. All the evaluation indices were surveyed every 4 weeks. In the probiotics group, there was asignificant decrease in the CADESI-4 score at 4, 8, and 12 weeks compared to that of the baseline score (p < 0.05). There was nosignificant difference in TEWL, PVAS, and medication score at each time point and between groups. Although these results showedthat Bifidobacterium longum did not reduce pruritus, TEWL, and the dosage of drugs for canine AD, it was effective in improving skinlesions, therefore, probiotics could be considered in canine AD with severe skin symptoms.

키워드

Atopic dermatitis; Bifidobacterium longum; dogs; probiotics
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