잠시만 기다려 주세요. 로딩중입니다.

경도에서 중등도의 안구건조증을 가진 정상안압녹내장에서 무보존제 라타노프로스트의 임상효과

Efficacy of Preservative-free Latanoprost in Normal-tension Glaucoma with Mild to Moderate Dry Eye

대한안과학회지 2020년 61권 6호 p.639 ~ 644
이송민, 진상욱,
소속 상세정보
이송민 ( Lee Song-Min ) - Dong-A University College of Medicine Department of Ophthalmology
진상욱 ( Jin Sang-Wook ) - Dong-A University College of Medicine Department of Ophthalmology

Abstract


Purpose: To evaluate the efficacy and safety of preservative-free latanoprost in patients with normal-tension glaucoma who had mild to moderate dry eye after switching from preserved latanoprost.

Methods: This retrospective study was conducted in patients with normal-tension glaucoma who had mild to moderate dry eye. All enrolled patients had used preserved latanoprost and switched to preservative-free Latanoprost. The study consisted of a baseline visit (treatment with preserved latanoprost) and four follow-up visits conducted after 1, 3, 6, and 12 months of treatment with preservative-free latanoprost. Intraocular pressure (IOP), mean deviation (MD), ocular surface disease index (OSDI), Shirmer’s test score, tear break-up time (TBUT), corneo-conjunctival fluorescein staining, and adverse drug reactions were evaluated.

Results: The mean IOP and MD values during treatment with preserved latanoprost were 14.1 ± 2.6 mmHg and -2.68 ± 0.11 dB, respectively. The mean IOP and MD values at 12 months after switching to preservative-free latanoprost were 13.9 ± 1.9 mmHg and -2.66 ± 0.12 dB, respectively. The OSDI, Shirmer’s test score, BUT, and corneo-conjunctival fluorescein staining during treatment with preserved latanoprost were 53.15 ± 8.86, 4.97 ± 1.71 mm, 4.92 ± 1.72 seconds, and 2.92 ± 1.05, respectively. The OSDI, Shirmer’s test score, TBUT, and corneo-conjunctival fluorescein staining at 12 months after switching to preservative-free latanoprost were 49.07 ± 6.97, 5.51 ± 1.48 mm, 5.49 ± 1.46 seconds, and 2.47 ± 1.09, respectively. There were no serious adverse drug reactions causing ocular damage.

Conclusions: Preservative-free latanoprost was effective for improving objective and subjective symptoms compared to preserved latanoprost; it maintained a stable IOP and visual field value in patients with normal-tension glaucoma who had mild to moderate dry eye.

키워드

Dry eye; Normal tension glaucoma; Monoprost ®; Preservative free latanoprost

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