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프로스타글란딘 제제의 장기 점안이 중심각막두께와 안압에 미치는 영향

The Long-term Effects of Prostaglandin Analogues on Central Corneal Thickness and Intraocular Pressure

대한안과학회지 2020년 61권 6호 p.650 ~ 657
송지은 ( Song Ji-Eun ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Ophthalmology

이미연 ( Lee Mi-Yeon ) - Kangbuk Samsung Hospital Department of Medical Information
정필욱 ( Chung Pil-Wook ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Neurology
김준모 ( Kim Joon-Mo ) - Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Ophthalmology

Abstract


Purpose: To evaluate the long-term effect of 0.005% latanoprost (LA) and 0.0015% tafluprost (TA) on intraocular pressure (IOP) and central corneal thickness (CCT) in glaucoma patients.

Methods: This study was a retrospective study, which enrolled open-angle glaucoma (OAG) patients treated with one of two prostaglandin analogues. The patients were observed for at least three years and underwent corneal thickness measurements at least once a year. Patients with a history of ocular surgery except cataract surgery or another glaucoma medication during the follow-up were excluded. Goldmann applanation tonometry and specular microscopy were used to measure the IOP and CCT, respectively. Changes in IOP and CCT were compared between the two groups.

Results: A total of 55 OAG patients (110 eyes) were enrolled. The patients were divided into two groups; one group (50 eyes) used LA as anti-glaucoma eye drops, and the other group (60 eyes) used TA. Statistically significant reductions in IOP and CCT were observed in both groups. The mean reduction in IOP over a three year period was -2.18 ± 2.83 mmHg in the LA group and -2.08 ± 2.40 mmHg in the TA group (paired t-test, p < 0.001, for both). In terms of CCT, the mean reduction was -20.24 ± 22.92 μm in the LA group and -32.90 ± 32.04 μm in the TA group (paired t-test, p < 0.001, for both) for three years. The decrease in CCT was not significantly different between the two groups (p = 0.061). There was no significant difference in the IOP reduction between the two drugs nor was there a significant correlation between the IOP and the CCT.

Conclusions: This study indicated that 0.005% LA and 0.0015% TA had similar effects on the reduction of IOP and CCT for three years without damaging the corneal endothelium.

키워드

Corneal thickness; Glaucoma; Intraocular pressure; Latanoprost; Tafluprost
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