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Phenothiazine 誘導體의 溶血作用에 關한 實驗的 硏究

Experimental Studies on the Hemolytic Action of Phenothiazine Derivatives

대한약리학잡지 1968년 4권 1호 p.9 ~ 16
이상우,
소속 상세정보
이상우 (  ) - 부산대학교 의과대학 약리학교실

Abstract


The author studied the hemolytic action of phenothiazine derivatives such as promazine, prochlorperazine, perphenazine and thiethylperazine on rabbit erythrocytes, and obtained the following results:
1. Promazine, prochlorperazine, perphenazine and thiethylperazine caused hemolysis in vitro in the following order:
Thiethylperazine> perphenazine>prochlorperazine>promazine.
2. Cholesterol inhibited the hemolytic action of prochlorperazine, perphenazine and thiethylperazine, but had no effect on promazine hemolysis.
3. Dextrose, albumin and blood plasma protected erythrocytes against promazine, prochlorperazine, perphenazine and thiethylperazine.
4. The intravenous injection of promazine, prochlorperazine, perphenazine and thiethylperazine caused hemolysis in the same order as they did in vitro.

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