잠시만 기다려 주세요. 로딩중입니다.

전신 스테로이드 및 고실 내 스테로이드 주입술 병용 요법을 이용한 특발성 돌발성 난청의 치료에서 고실 내 스테로이드 주입 시작 시기에 따른 치료 결과

Hearing Outcome According to the Intratympanic Steroid Injection Starting Timing in Combined Intratympanic and Oral Steroid Treatment for Idiopathic Sudden Sensorineural Hearing Loss

대한이비인후과학회지-두경부외과학 2020년 63권 10호 p.448 ~ 457
이현민, 박다희, 김동조, 최성원, 오세준, 공수근, 이일우,
소속 상세정보
이현민 ( Lee Hyun-Min ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
박다희 ( Park Da-Hee ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
김동조 ( Kim Dong-Jo ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
최성원 ( Choi Sung-Won ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
오세준 ( Oh Se-Joon ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
공수근 ( Kong Soo-Keun ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery
이일우 ( Lee Il-Woo ) - Pusan National University College of Medicine Department of Otorhinolaryngology-Head and Neck Surgery

Abstract


Background and Objectives: The combined intratympanic and oral steroid treatment has been accepted as effective treatment strategy for idiopathic sudden sensorineural hearing loss (ISSNHL). However, the treatment protocol of combined treatment for ISSNHL has not been established. In this study, we investigated whether hearing outcome differed according to different starting timing of intratympanic steroid injection (ITSI) in combined treatment for ISSNHL.

Subjects and Method: Tertiary academic referral center-based retrospective medical records of idiopathic 144 ISSNHL patients who received combined treatment from January 2015 to April 2018 were reviewed. All patients underwent a 2-week oral systemic steroid treatment and multiple ITSI. The hearing results of 3 months after treatment were compared according to the timing of ITSI.

Results: The mean pure tone audiogram gain was 24.3±23.6 dB. When Siegel’s criteria was applied, the overall rate of hearing improvement was 63.9% (92/144). The rate of hearing improvement was significantly higher in women (p=0.043) statistically, and there was a statistically significant lower rate of recovery in the former history of hearing loss (p<0.01) or otitis media (p<0.01). Moreover, the shorter the delay between symptom onset and initial ITSI, greater the statistical significance of hearing recovery rate became (p<0.01).

Conclusion: The result of this study suggests that early ITSI during combined intratympanic and oral steroid treatment increases the chance of hearing recovery.

키워드

Hearing loss; sudden; Injection; intratympanic; Steroids

원문 및 링크아웃 정보

등재저널 정보