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Macrophages in xenotransplantation

대한이식학회지 2019년 33권 4호 p.74 ~ 82
김재영 ( Kim Jae-Young ) - Gachon University Department of Life Science

Abstract


Xenotransplantation refers to organ transplantation across species. Immune rejection of xenografts is stronger and faster than that of allografts because of significant molecular differences between species. Recent studies have revealed the involvement of macrophages in xenograft and allograft rejections. Macrophages have been shown to play a critical role in inflammation, coagulation, and phagocytosis in xenograft rejection. This review presents a recent understanding of the role of macrophages in xenograft rejection and possible strategies to control macrophage-mediated xenograft rejection.

키워드

Xenotransplantation; Macrophages; Inflammation; Coagulation
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