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Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study

대한이식학회지 2020년 34권 3호 p.154 ~ 166
고형원, Koo Kyung-Lim, 신창식, 박형섭, 정종철, 김세중, 채동완, 오종진, 변석수, 이태승,
소속 상세정보
고형원 ( Koh Hyoung-Won ) - Seoul National University Bundang Hospital Department of Surgery
 ( Koo Kyung-Lim ) - Seoul National University Bundang Hospital Department of Surgery
신창식 ( Shin Chang-Sik ) - Seoul National University Bundang Hospital Department of Surgery
박형섭 ( Park Hyung-Sub ) - Seoul National University Bundang Hospital Department of Surgery
정종철 ( Jeong Jong-Cheol ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine
김세중 ( Kim Se-Joong ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine
채동완 ( Chae Dong-Wan ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Internal Medicine
오종진 ( Oh Jong-Jin ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Urology
변석수 ( Byun Seok-Soo ) - Seoul National University College of Medicine Seoul National University Bundang Hospital Department of Urology
이태승 ( Lee Tae-Seung ) - Seoul National University Bundang Hospital Department of Surgery

Abstract


Background: Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has increased rapidly as more centers are implementing a transplantation program. The objective of this study was to determine clinical outcomes of the first 300 consecutive cases of KT in a single center.

Methods: Clinical data of 300 cases of KT at Seoul National University Bundang Hospital from January 2004 to March 2018 were obtained from a prospectively collected database and retrospectively reviewed.

Results: The mean age of patients was 47.7±12.9 years, and 59% of patients were male. There were 225 living donors and 75 deceased donors. A total of 42 cases were from ABO-incompatible donors. During a mean follow-up of 68.6±43.5 months, 38 patients (12.7%) experienced rejection. The most common cause was acute T-cell mediated rejection (9.0%). Eighteen patients experienced graft loss. One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively. One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively. Multivariate analysis revealed that graft weight-to-recipient weight ratio and rejection were significant factors affecting graft survival.

Conclusions: This single-center review demonstrates clinical outcomes comparable to other major centers. Such good outcomes were obtained by good patient selection, dedicated transplant physicians, and adequate use of immunosuppressive therapy.

키워드

Transplantation; Kidney transplantation

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