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Impact of extended-criteria donor lungs according to preoperative recipient status and age in lung transplantation

대한이식학회지 2020년 34권 3호 p.185 ~ 192
서지원, 이진구, 박무석, 김송이, 정수진, 백효채,
소속 상세정보
서지원 ( Suh Jee-Won ) - Yonsei University College of Medicine Yongin Severance Hospital Department of Thoracic and Cardiovascular Surgery
이진구 ( Lee Jin-Gu ) - Yonsei University College of Medicine Severance Hospital Department of Thoracic and Cardiovascular Surgery
박무석 ( Park Moo-Suk ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
김송이 ( Kim Song-Yee ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
정수진 ( Jeong Su-Jin ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine
백효채 ( Paik Hyo-Chae ) - Yonsei University College of Medicine Severance Hospital Department of Thoracic and Cardiovascular Surgery

Abstract


Background: Organ donor shortage remains as one of the limiting factors for lung transplantation. Given the increase in waiting time, preoperative condition has worsened and affects surgical outcomes. This study aimed to evaluate the immediate postoperative and long-term outcomes of lung transplantation in extended-criteria donor (ECD) lungs compared with standard-criteria donor (SCD) lungs.

Methods: A total of 246 patients who had undergone double-lung transplantation during the study period were enrolled. SCD was defined based on the following characteristics: age <55 years, <20 pack-years smoking history, and PaO2/fraction of O2 ratio >300 mmHg. Organ donors who do not fulfill these criteria were classified as ECD. Pre- and postoperative data for outcomes and survival data were analyzed.

Results: ECD showed significant association with extracorporeal membrane oxygenation weaning in the operating room (hazard ratio [HR], 0.531; 95% confidence interval [CI], 0.291?0.970; P=0.039) considering recipient’s age and status at operation. The ECD group showed comparable survival rate with the SCD group (HR, 1.413; 95% CI, 0.885? 2.255; P=0.148), with adjustment of other factors. However, when the recipient had Korean Network for Organ Sharing (KONOS) status 0 at the time of transplantation (HR, 1.662; 95% CI, 1.025?2.568; P=0.039), G3 primary graft dysfunction at 72 hours after surgery (HR, 2.508; 95% CI, 1.416?4.440; P=0.002) was a risk factor that decreased survival.

Conclusions: The outcome of ECD is not inferior to that of SCD. Therefore, ECD lung should be considered a potential donor organ following active donor management rather than a contraindication of transplantation in highly selected recipients.

키워드

Lung transplantation; Donor; Extended criteria donor

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