잠시만 기다려 주세요. 로딩중입니다.

Etiopathogenesis of sacroiliitis: implications for assessment and management

Korean Journal of Pain 2020년 33권 4호 p.294 ~ 304
Baronio Manuela, Sadia Hajra, Paolacci Stefano, Prestamburgo Domenico, Miotti Danilo, Guardamagna Vittorio A., Natalini Giuseppe, Bertelli Matteo,
소속 상세정보
 ( Baronio Manuela ) - Fondazione Poliambulanza Dipartimento di Anestesia, Rianimazione, Terapia Intensiva e del Dolore
 ( Sadia Hajra ) - National University of Sciences and Technology Atta-ur-Rahman School of Applied Biosciences
 ( Paolacci Stefano ) - MAGI’s Lab
 ( Prestamburgo Domenico ) - Ospedali Civili di Legnano e Cuggiono Ortopedia e Traumatologia
 ( Miotti Danilo ) - ICS Maugeri Cure Palliative e Terapia del Dolore
 ( Guardamagna Vittorio A. ) - IRCCS IEO Cure Palliative e Terapia del Dolore
 ( Natalini Giuseppe ) - Fondazione Poliambulanza Dipartimento di Anestesia, Rianimazione, Terapia Intensiva e del Dolore
 ( Bertelli Matteo ) - MAGI’s Lab

Abstract


The sacroiliac joints connect the base of the sacrum to the ilium. When inflamed, they are suspected to cause low back pain. Inflammation of the sacroiliac joints is called sacroiliitis. The severity of the pain varies and depends on the degree of inflammation. Sacroiliitis is a hallmark of seronegative spondyloarthropathies. The presence or absence of chronic sacroiliitis is an important clue in the diagnosis of low back pain. This article aims to provide a concise overview of the anatomy, physiology, and molecular biology of sacroiliitis to aid clinicians in the assessment and management of sacroiliitis. For this narrative review, we evaluated articles in English published before August 2019 in PubMed. Then, we selected articles related to the painful manifestations of the sacroiliac joint. From the retrieved articles, we found that chronic sacroiliitis may be caused by various forms of spondyloarthritis, such as ankylosing spondyloarthritis. Sacroiliitis can also be associated with inflammatory bowel disease, Crohn’s disease, gout, tuberculosis, brucellosis, and osteoarthritis, indicating common underlying etiological factors. The pathophysiology of sacroiliitis is complex and may involve internal, environmental, immunological, and genetic factors. Finally, genetic factors may also play a central role in progression of the disease. Knowing the genetic pre-disposition for sacroiliitis can be useful for diagnosis and for formulating treatment regimens, and may lead to a substantial reduction in disease severity and duration and to improved patient performance.

키워드

Inflammation; Inflammatory Bowel Diseases; Low Back Pain; Sacroiliac Joint; Sacroiliitis; Sacrum; Spondylitis; Ankylosing; Spondyloarthropathies

원문 및 링크아웃 정보

 

등재저널 정보