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Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain

Korean Journal of Pain 2020년 33권 4호 p.326 ~ 334
최근주, 강현, 이준모, 백종화, 정용훈, 우영철, 도재혁, 고진수,
소속 상세정보
최근주 ( Choi Geun-Joo ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
강현 ( Kang Hyun ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
이준모 ( Lee Jun-Mo ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
백종화 ( Baek Chong-Wha ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
정용훈 ( Jung Yong-Hun ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
우영철 ( Woo Young-Cheol ) - Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine
도재혁 ( Do Jae-Hyuk ) - Chung-Ang University College of Medicine Department of Internal Medicine
고진수 ( Ko Jin-Soo ) - National Police Hospital Department of Plastic Surgery

Abstract


Background: In this study, we sought to evaluate whether systemic propentofylline (PPF) has antiallodynic effects in a rat model of postoperative pain, and to assess the mechanism involved.

Methods: After plantar incision, rats were intraperitoneally injected with various doses of PPF to evaluate its antiallodynic effect. To investigate the involved mechanism, rats were intraperitoneally injected with yohimbine, dexmedetomidine, prazosin, naloxone, atropine or mecamylamine, following the incision of the rat hind paws, and then PPF was administered intraperitoneally. The mechanical withdrawal threshold (MWT) was evaluated using von Frey filaments at various time points and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were measured to determine the inflammatory response level.

Results: MWT was significantly increased after intraperitoneal injection of 30 mg/kg of PPF when compared with the control group. Injection of PPF and yohimbine, atropine or mecamylamine showed significant decreases in the MWT, while injection of PPF and dexmedetomidine showed a significant increase. Systemic administration of PPF inhibited the post-incisional increase in serum level of TNF-α and IL-1β.

Conclusions: Systemic administration of PPF following surgery presented antiallodynic effects in a rat model of postoperative pain. The antiallodynic effects against mechanical allodynia could be mediated by α-adrenergic and cholinergic receptors.

키워드

Acute pain; Animals; Hyperalgesia; Injections; Intraperitoneal; Pain; Pain Management; Pain; Postoperative; Propentofylline; Rats

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