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Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain

Korean Journal of Pain 2020년 33권 4호 p.395 ~ 399
성현영, 김량규, 신영재, 이혜원, 고재철,
소속 상세정보
성현영 ( Seong Hyun-Young ) - Korea University Anam Hospital Department of Anesthesiology and Pain Medicine
김량규 ( Kim Raing-Kyu ) - Korea University Anam Hospital Department of Anesthesiology and Pain Medicine
신영재 ( Shin Young-Jae ) - Korea University Anam Hospital Department of Anesthesiology and Pain Medicine
이혜원 ( Lee Hye-Won ) - Korea University Anam Hospital Department of Anesthesiology and Pain Medicine
고재철 ( Koh Jae-Chul ) - Korea University Anam Hospital Department of Anesthesiology and Pain Medicine

Abstract


Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage.

Methods: Patients treated with PAC were retrospectively evaluated. Patients with chronic refractory pain, suspected to have originated from musculoskeletal damage or defects with the evidence of imaging studies were included. Pain intensity, using the 11-point numerical rating scale (NRS), was assessed before the procedure, and 1 month after the last procedure.

Results: Eighty-eight patients were finally included for investigation. The mean NRS score was decreased from 5.8 to 4.1 after 1 month of PAC injection (P < 0.001). No independent factor was reported to be directly related to the decrease in NRS score by more than half.

Conclusions: Application of PAC may have potential as a treatment option for refractory chronic musculoskeletal pain. PAC might promote tissue recovery, act as a scaffold for repair, or directly reduce inflammation.

키워드

Chronic Pain; Collagen; Connective Tissue; Injections; Musculoskeletal Pain; Pain Management; Procollagen; Regenerative Medicine

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