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DMSO 皮膚局所塗布가 紫外線 照射에 미치는 影響에 關한 硏究

Influence of Dimethyl Sulfoxide on the Effect of Ultraviolet Irradiation

대한피부과학회지 1970년 8권 1호 p.11 ~ 17
김수남, 李惟信,
소속 상세정보
김수남 (  ) - 서울대학교 醫科大學 皮膚科學敎室
李惟信 (  ) - 서울대학교 醫科大學 皮膚科學敎室

Abstract


Various concentrations, including 100%, 75%, 50%, and 25% of dmethyl sulfoxide (DMSO) were applied on the back of albino rats, followed by ultraviolet irradiation after 30 minutes. Biopsy specimens were taken, 6, 12, 24, 36, and 48 hours afters ultraviolet irradiation without local anesthesia. The macroscopic and histologic findings were as follows.
1. Mild degree of erytheme appeared only on the site of the highest concentration (100%) of DMSO.
2. Vacuolization of the prickle cells appeared slightly later on the sites of higher concentrations (75% and 100%) than those of lower concentrations and control.
3. After 48 hours post-irradiation, there was no detectable vacuolization on the sites of higher concentrations, whereas marked vacuolization still remained on the other sites.
4. More pronounced epidermal thickening could be observed on the sites of higher concentrations than the sites of lower concentrations and control.
5. The dermal edema was more completely disappeared on the sites of higher concentrations than the sites of lower concentrations and control, 48 hours after ultraviolet irradiation.

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