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皮膚基底膜의 硏究

Study on the Basement Membrane

대한피부과학회지 1970년 8권 2호 p.3 ~ 15
김성환, 金源錫,
소속 상세정보
김성환 (  ) - 서울대학교 醫科大學 皮膚科學敎室
金源錫 (  ) - 서울대학교 醫科大學 皮膚科學敎室

Abstract


One hundred and four biopsy specimens of various dermatoses were stained with Periodic Acid-Schiff and examined. The lesions were grouped into five groups; A. twenty two cases of vesicobullous diseases; B. twenty one cases of maculopapulosquamous diseases; C. eighteen cases of chronic granulomatous infection; D. seventeen- cases of precancerosis and benign and malignant neoplasms; and E. twenty six cases of miscellaneous skin diseases. Special attention was given to the morphological changes of the dermoepidermal junction and the basement membrane.
The results were as follows.
1. Among 10 cases of erythema multiforme, partial fraying appeared in 4 cases, partial thickening in 4 and hyperchromasia in 4. Marked convolution was noted in the thickened basement membrane. PAS-positive material was scattered in the edemateus papillary dermis in some cases.
2. All of 6 cases of pemphigus erythematosus and pemphigus vulgaris showed normal basement membrane.
3. In bullous pemphigoid, partial absence in the areas of bulla formation appeared in 2 cases among 3 cases. PAS positive material was present within the bullae and in the upper dermis.
4. All of 3 cases of dermatitis herpetiformis showed partial absence or fraying.
5. Half of 10 cases of psoriasis showed normal basement membrane. Among the remainder, fraying and partial thickening appeared in 3 and 2 cases respectively.
6. Among 6 cases of lichen planus, almsot total absence appeared in 2 cases and fraying in 3 cases. PAS positive material appeared focally in the upper dermis in some cases.
7. Four of 5 cases of pityriasis rubra pilaris showed diffuse thickening and marked convolution of the basement membrane.
8. Half of 4 cases of lupus vulgaris showed normal basement membrane. Fraying and partial thickening appeared in 2 and 2 cases respectively.
9. All but 1 among 5 cases of lepromatous leprosy showed poor staining and poor visualization, of the basement membrane.
10. One case of tuberculoid leprosy showed partial fraying, partial thickening and hyperchromasia. with marked convolution, among 5 cases.
11. Among 4 cases of condyloma latum, only one showed partial fraying.
12. One of 3 cases of senile keratosis showed partial fraying of the basemement membrane.
13. One case of Bowen´s disease showed partial thickening and hyperchromasia among 3 cases PAS-positive material was present focally in the upper dermis in some cases.
14. All of 6 cases of basal cell carcinoma, showed normal basement membrane. PAS-positive material were present focally in the uppermost dermis in some oases.
15. All of 3 cases of squamous cell carcinoma showed total absence of the basement membrane
16. All of the 2 cases of keratoacanthoma showed partial fraying.
17. Among 10 cases of chronic discoid lupus erythematosus, 9 cases showed partial thickening and hyperchromasia with marked convolution of the basement membrane. Two cases showed partial´ fraying in areas of marked liquefaction degeneration of the basal cells. PAS-positive material appeared in the uppermost dermis in some cases.
18. All of 3 cases of fixed drug eruption, 2 cases of seborrheic keratosis and 6 cases of verrucae showed normal basement membrane.
19. Ofie case of poikiloderma atrophicans vasculare showed partial fraying, among 2 cases.
20. All of 2 cases of chronic radiodermatitis showed diffuse thickening and hyperchromasia. The thickened basement membrane showed marked convolution focally.

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