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광선각화증 환자에서 Ingenol Mebutate Gel의 치료 효과 및 국소피부반응

The Effectiveness and Local Skin Reactions of Ingenol Mebutate Gel in Patients with Actinic Keratosis

대한피부과학회지 2020년 58권 3호 p.155 ~ 161
신영빈 ( Shin Young-Bin ) - 경상대학교 의과대학 피부과학교실

김지연 ( Kim Chi-Yeon ) - 경상대학교 의과대학 피부과학교실

Abstract


Background: Actinic keratosis (AK) is a common skin disease caused by exposure to ultraviolet light that can progress to invasive squamous cell carcinoma. Ingenol mebutate (IM), a novel agent for field therapy of AK, has been widely used, but research on its effectiveness has focused more on Caucasian rather than Asian people.
Objective: The effectiveness and local skin reaction of IM gel treatment in Koreans were investigated through long-term follow-up.

Methods: We retrospectively reviewed 17 patients histopathologically diagnosed with AK on the face/scalp and treated with IM gel (0.015%) between 2015 and 2017. The clinical efficacy and local skin reactions were assessed from medical records. The long-term effects of IM gel treatment were evaluated after 6 months of treatment.

Results: Nine of the 17 (52.9%) subjects had a complete response at day 57. Although the patients developed erythema (100%), flaking/scaling (76%), crusting (47%), swelling (64%), vesiculation/pustulation (70%), and erosion/ ulceration (35%) as a local skin reactions at day 4, most of these reactions had disappeared at day 57. Most of the patients (76.5%) complained of pain or irritation as side effects. The long-term efficacy was assessed in two patients with a complete response at day 57 and the complete response was sustained for all patients at 6 months.

Conclusion: IM seems to be an effective field therapy for multiple AK lesions with short-term use and stability.
Further studies are needed on the effects of IM therapy in the Korean population.

키워드

Actinic keratosis; Field therapy; Ingenol mebutate
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KCI
KoreaMed
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