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Case Reports of Spitz Nevus with a Halo Phenomenon

대한피부과학회지 2020년 58권 3호 p.207 ~ 211
최명은 ( Choi Myoung-Eun ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology

이우진 ( Lee Woo-Jin ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
장성은 ( Chang Sung-Eun ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
최지호 ( Choi Jee-Ho ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology
이미우 ( Lee Mi-Woo ) - University of Ulsan College of Medicine Asan Medical Center Department of Dermatology

Abstract


Halo nevus clinically presents as a nevus with a surrounding ring of depigmentation that histopathologically demonstrates a dense lymphocytic reaction to the melanocytic component of the epidermis. While melanocytic nevi with halo phenomena are common, a halo reaction is uncommon in Spitz nevus. When a halo reaction develops around a Spitz nevus, differential diagnosis from melanoma arising from pre-existing nevus is difficult due to the presence of dense inflammatory components. A halo reaction itself can increase the cytologic atypia of melanocytes and can obscure nest maturation. Herein, we report rare cases of Spitz nevus combined with a halo reaction. It is important to note that the halo phenomenon can occur without a clinically evident white patch and that the architectural features of the nevus components can be used to distinguish Spitz nevus from malignant melanoma.

키워드

Halo nevus; Melanoma; Immune response; Spitz nevus
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