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Epidermotropic Metastasis from Lung Adenocarcinoma

대한피부과학회지 2020년 58권 5호 p.347 ~ 349
정혜정 ( Jung Hye-Jung ) - National Medical Center Department of Dermatology

박미연 ( Park Mi-Youn ) - National Medical Center Department of Dermatology
이재인 ( Lee Jae-In ) - National Medical Center Department of Dermatology
배주윤 ( Bae Joo-Youn ) - National Medical Center Department of Dermatology
안지영 ( Ahn Ji-Young ) - National Medical Center Department of Dermatology

Abstract


Cancer metastasis to the skin, especially epidermotropic metastasis, is uncommon. Sometimes it is difficult to find the primary lesion; immunohistochemical (IHC) staining of cutaneous metastasis is used to determine the origin, but diagnosis may occasionally prove difficult. A 77-year-old man visited our hospital with a 1-month diagnostic history of multiple nodules in the right axilla. The patient had undergone surgery for gastric adenocarcinoma (T3N3M0) 21 years ago, and was diagnosed with lung adenocarcinoma 1 year previously; however, no treatment was ongoing.
Biopsy of the lesions revealed atypical cells surrounding the papillary projections of the epidermis and tumor nests of the upper dermis. IHC staining was positive for CK7 and CEA and negative for CK5/6, CK20, napsin A, TTF-1, GCDFP 15, and p63. The tissues revealed glandular structures and tested negative for p63 and CK5/6 on IHC staining. The patient was diagnosed with epidermotropic metastasis of lung adenocarcinoma.

키워드

Lung adenocarcinoma; Neoplasm metastasis
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