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Skin Barrier Dysfunction in the Scalp, Nails, and Lips in Patients with Atopic Dermatitis

대한피부과학회지 2020년 58권 8호 p.525 ~ 529
이찬양, 정기헌, 신민경,
소속 상세정보
이찬양 ( Lee Chan-Yang ) - Kyung Hee University School of Medicine Department of Dermatology
정기헌 ( Jeong Ki-Heon ) - Kyung Hee University School of Medicine Department of Dermatology
신민경 ( Shin Min-Kyung ) - Kyung Hee University School of Medicine Department of Dermatology

Abstract


Background: Atopic dermatitis is a chronic, inflammatory disease affecting the skin including the scalp, nails, and lips. One of the main pathogenesis of atopic dermatitis is skin barrier impairment. Transepidermal water loss is a noninvasive measurement of water loss across the stratum corneum for assessing skin barrier function.

Objective: This study aimed to evaluate the skin barrier function of various skin sites including hairy skin, non-keratinized areas, and hard keratin in patients with atopic dermatitis. Furthermore, the relationship between the severity of atopic dermatitis and transepidermal water loss was investigated.

Methods: In total, 73 patients with atopic dermatitis and 65 age-matched healthy controls were included in this study. Transepidermal water loss was measured at 8 different skin sites including hairy skin (vertex, occiput), the cheek, non-keratinized area (lower lip), lateral side of the upper arm, flexor side of the forearm, extensor side of the forearm, and hard keratin (fingernail). The severity of atopic dermatitis was assessed using the eczema area and severity index.

Results: Transepidermal water loss was observed to be higher at all the measured sites including the scalp, nails, and lips of atopic dermatitis patients in comparison with that of the age-matched controls. Transepidermal water loss were correlated with the severity of atopic dermatitis in the cheek, lips, upper arm, and forearm.

Conclusion: Patients with atopic dermatitis have impaired skin barrier function, including in regions of hairy skin, non-keratinized areas, and hard keratin areas. Barrier dysfunction is associated with the severity of atopic dermatitis.

키워드

Dermatitis; atopic; Severity of illness index; Water loss; Skin barrier

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