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Elevated Serum Leptin Receptor and Insulin-like Growth Factor-1 Levels and High Levels of Leptin Receptor Expression in Acanthosis Nigricans Patients: Serologic and Histopathologic Analyses

대한피부과학회지 2020년 58권 8호 p.530 ~ 536
김원오, 김현욱, 조현재, 류영욱, 정혜라, 김성애,
소속 상세정보
김원오 ( Kim Won-Oh ) - Keimyung University School of Medicine Department of Dermatology
김현욱 ( Kim Hyun-Wook ) - Keimyung University School of Medicine Department of Dermatology
조현재 ( Joe Hyun-Jae ) - Keimyung University School of Medicine Department of Dermatology
류영욱 ( Ryoo Young-Wook ) - Keimyung University School of Medicine Department of Dermatology
정혜라 ( Jung Hye-Ra ) - Keimyung University School of Medicine Department of Pathology
김성애 ( Kim Sung-Ae ) - Keimyung University School of Medicine Department of Dermatology

Abstract


Background: Acanthosis nigricans is characterized by a velvety thickening of the epidermis accompanied by different degrees of hyperpigmentation, and known to be linked to obesity and insulin resistance.

Objective: We aimed to analyze obesity-related factors in acanthosis nigricans patients and to evaluate the correlations between acanthosis nigricans and various factors.

Methods: From January 2004 to February 2015, 27 acanthosis nigricans patients participated in this study. Blood samples were collected from a control group of seven overweight people and from the seven acanthosis nigricans patients, and they were analyzed for different obesity-related factors. Skin samples were collected from the 23 acanthosis nigricans patients and from 11 patients with epidermal nevi, and immunohistochemistry was performed to detect the presence of adiponectin receptor 1, adiponectin receptor 2, and the leptin receptor.

Results: The median serum leptin level in the acanthosis nigricans patients (13 ng/mL) was significantly higher than that in the overweight control individuals (8.9 ng/mL) (p=0.021). The acanthosis nigricans patients had significantly higher levels of insulin-like growth factor-1 in their serum samples (p=0.017). The immunohistochemical analysis determined that the skin from the acanthosis nigricans patients stained significantly more intensely for the leptin receptor compared with that seen in the skin from the patients with epidermal nevi (p=0.002).

Conclusion: In conclusion, this study’s findings suggest that the levels of leptin and insulin-like growth factor-1 in the serum, and the expression of the leptin receptor in the skin are elevated with acanthosis nigricans.

키워드

Acanthosis nigricans; Adipokine; Insulin-like growth factor-1; Leptin; Leptin receptor

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