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Risk of Cardiovascular Disease in Patients with Behcet Disease: A Population-based Retrospective Cohort Study in Korea

대한피부과학회지 2020년 58권 9호 p.608 ~ 613
권준교, 장주왕, 박세광, 오세욱, 강호송, 김정수, 서현민,
소속 상세정보
권준교 ( Gwon Jun-Gyo ) - Korea University Anam Hospital Department of Transplantation and Vascular Surgery
장주왕 ( Jang Ju-Wang ) - Hanyang University Guri Hospital Department of Dermatology
박세광 ( Park Se-Kwang ) - Hanyang University Guri Hospital Department of Dermatology
오세욱 ( Oh Se-Uk ) - Hanyang University Guri Hospital Department of Dermatology
강호송 ( Kang Ho-Song ) - Hanyang University Guri Hospital Department of Dermatology
김정수 ( Kim Joung-Soo ) - Hanyang University Guri Hospital Department of Dermatology
서현민 ( Seo Hyun-Min ) - Hanyang University Guri Hospital Department of Dermatology

Abstract


Background: Few studies have investigated the association between Behcet disease (BD) and cardiovascular disease (CVD). The aim of this study was to investigate the risk of various CVDs in patients with BD.

Objective: The aim of this study was to investigate the risk of various CVD in patients with BD.

Methods: Between 2003 and 2015, we performed a retrospective cohort study involving patients with BD selected from Korea’s National Health Insurance Service-National Sample Cohort database and age- and sex-matched controls. Age- and sex-matched controls were selected randomly from the NHIS-NSC database at a frequency of 1:5.

Results: Among the 998 patients with BD and the 4,990 controls studied, patients with BD showed significantly higher risk for angina pectoris (adjusted Hazard Ratio [HR] 1.522, 95% confidence interval [CI] 1.020∼2.273; p=0.04) and peripheral arterial disease (adjusted HR 2.939, 95% CI 1.296∼6.664; p=0.01) than the controls. The cumulative incidence rates of these diseases in patients with BD were also significantly higher than those in the controls.

Conclusion: Patients with BD showed independent risk for angina pectoris and peripheral arterial disease.

키워드

Behcet disease; Cardiovascular diseases; Coronaryartery disease; National health programs; Peripheral arterial disease

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