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천식환자 허실변증별 혈액 싸이토카인 및 임상적 특성에 관한 단면적 연구

A Cross-sectional Study of Deficiency-Excess Pattern Identification with Blood Cytokines and Characteristics of Patients with Asthma

대한한방내과학회지 2020년 41권 4호 p.583 ~ 598
유창환, 강성우, 홍성은, 김관일, 이범준, 정희재,
소속 상세정보
유창환 ( Yu Chang-Hwan ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine
강성우 ( Kang Sung-Woo ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine
홍성은 ( Hong Sung-Eun ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine
김관일 ( Kim Kwan-Il ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine
이범준 ( Lee Beom-Joon ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine
정희재 ( Jung Hee-Jae ) - Kyung Hee University Graduate School of Korean Medicine Department of Internal Medicine

Abstract


Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma.

Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups.

Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation.

Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.

키워드

asthma; pattern identification; deficiency-excess pattern; blood cytokine; QLQAKA; visual analogue scale (VAS)

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