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마황, 인삼, 택사 복합추출물의 endocannabinoid system 억제를 통한 비알콜성 지방간 유도 인슐린저항성 개선 효과

The Efficacy of Ephedra sinica, Panax ginseng, and Alisma orientale Extract on Insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD)

대한한방소아과학회지 2020년 34권 4호 p.11 ~ 21
김기봉, 안상현,
소속 상세정보
김기봉 ( Kim Ki-Bong ) - Pusan National University School of Korean Medicine Department of Korean Pediatrics
안상현 ( Ahn Sang-Hyun ) - Semyung University College of Korean Medicine Department of Anatomy

Abstract


Objectives: This study aimed to investigate the efficacy of Ephedra sinica (E. sinica), Panax ginseng (P. ginseng), and Alisma orientale (A. orientale) Extract (MIT) on insulin resistance induced by Non-alcoholic fatty liver disease (NAFLD).

Methods: C57BL /6 male mice (8-week-old, 20 g) were divided into four groups: control group (Ctrl), high-fat diet group (HFDF), high fat diet with metformin administration group (METT), and high fat diet with MIT administration group (MITT). Each 10 mice were allocated to each group (a total of 40 mice). All mice were allowed to eat fat-rich diet freely throughout the experiment. To examine the effect of MIT, we observed Cannabinoid receptor type 1 (CB1), Cannabinoid receptor type 2 (CB2), G protein-coupled receptor 55 (GPR55), and Transforming growth factor-β (TGF-β).

Results: In the MITT group, positive reactions of the CB1, CB2, and GPR55 were significantly was significantly suppressed compared to the HFDF group. The positive reactions of the CD36 and TGF-β in the liver tissue were significantly suppressed in MITT.

Conclusions: MIT has the effect of improving NAFLD induced insulin resistance through the regulation of the lipid metabolism.

키워드

Ephedra sinica; Panax ginseng; Alisma orientale; Non-alcoholic fatty liver disease; Insulin resistance

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