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소아 변비의 한약 치료에 대한 최신 임상연구 동향- 중국 RCT 연구를 중심으로 -

Recent Trends in Clinical Research of Herbal Medicine Treatment for Pediatric Constipation - Focused on Chinese Randomized Controlled Trials -

대한한방소아과학회지 2020년 34권 4호 p.59 ~ 76
김재현, 박용석, 이지홍, 장규태,
소속 상세정보
김재현 ( Kim Jae-Hyun ) - Kyung Hee University Hospital at Gangdong Department of Pediatrics of Korean Medicine
박용석 ( Park Yong-Seok ) - Kyung Hee University Hospital at Gangdong Department of Pediatrics of Korean Medicine
이지홍 ( Lee Ji-Hong ) - Kyung Hee University Hospital at Gangdong Department of Pediatrics of Korean Medicine
장규태 ( Chang Gyu-Tae ) - Kyung Hee University Hospital at Gangdong Department of Pediatrics of Korean Medicine

Abstract


Objectives: The purpose of this study is to analyze the trends of recent clinical studies on the effect of herbal medicine for pediatric constipation in China, and to evaluate the efficacy and safety of herbal medication treatment for pediatric constipation.

Methods: The authors searched the clinical studies using China National Knowledge Infrastructure (CNKI) published from January 2016 to June 2020. We analyzed the literature in regards to focusing on the treatment methods and results.

Results: A total of 29 randomized controlled trials were selected and analyzed. In all the those studies, the total effective rate of herbal medicine treatment group in pediatric constipation was significantly higher than those of the control group. The most commonly used herbs for pediatric constipation were Atractylodis Rhizoma Alba (白朮) followed by Aurantii Immaturus Fructus (枳實), Glycyrrhizae Radix (甘草), Semen Cannabis (火麻仁), Raphani Semen (萊?子). The recurrence rate of the herbal medicine treatment group was significantly lower than those of control group. In most studies, the adverse events from the herbal medicine treatment group were significantly less than those of the control group.

Conclusions: Based on the results of the analyzed clinical studies, herbal medicine treatment has been shown to be safe and effective in the treatment of pediatric constipation. Additional clinical studies are needed to solidify these findings.

키워드

Pediatric constipation; Herbal medicine; Chinese journal; Review

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