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미생물에 대한 항균효과를 이용한 한약 전탕팩의 유효기한 연구

Establishment of the Expiration Date of Herbal Formula Decoction Pouch by Antimicrobial Activities Against Microorganisms

대한한의학회지 2020년 41권 2호 p.1 ~ 8
하혜경 ( Ha Hye-Kyung ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division

최순용 ( Choi Soon-Yong ) - Hannam University Department of Biotechnology
최순용 ( Choi Soon-Yong ) - Hannam University Department of Biotechnology
서창섭 ( Seo Chang-Seob ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
이나리 ( Lee Na-Ri ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division
신현규 ( Shin Hyeun-Kyoo ) - Korea Institute of Oriental Medicine Herbal Medicine Research Division

Abstract


Objectives: To establish the expiration date of herbal decoction pouch, the change in antimicrobial activities was measured according to storage temperature and period.

Methods: Five herbal formulas, Gyeji-tang, Jakyakgamcho-tang, Saengmaek-san, Paljung-san, and Dangguisu-san, with antimicrobial activity were selected from 51 herbal formulas commonly used in traditional Korean medical institutions. Five herbal formula decoction pouches were prepared and stored at room temperature (RT) or 4℃ from 0 to 12 weeks to evaluate the antimicrobial activity against Bacillus cereus, Listeria monocytogenes, or Vibrio parahaemolyticus. The antimicrobial activities were evaluated by the disk diffusion method (disk size: 10 mm).

Results: The decoction pouches of Gyeji-tang and Jakyakgamcho-tang maintained antimicrobial activity against V. parahaemolyticus from week 0 (14 mm) to week 12 (14 mm) at both temperatures. Saengmaek-san pouch had antimicrobial activities against V. parahaemolyticus and B. cereus from week 0 (19 mm and 20 mm) to week 12 (both 18 mm), respectively. At RT and 4℃, the antimicrobial activity of Paljung-san pouch was maintained week 0 (17 mm) to week 12 (both 13 mm) against B. cereus. Against L. monocytogenes, the antimicrobial activity of Dangguisu-san pouch showed 27 mm at week 0 and 23 mm (RT) and 24 mm (4℃) at week 12, respectively.

Conclusion: According to increase of the storage duration, the antimicrobial activities of 5 herbal formula decoction pouches decreased slightly but remained up to 12 weeks. These results can be used as important data to establish the expiration date of herbal formula decoction pouches.

키워드

herbal formula; decoction pouch; expiration date; antimicrobial activity
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