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Effects of X-irradiation on the Oxygen Consumption and Lysine Uptake of HeLa Cells in the Presence of Metabolic Substrates and Inhibitors

한국동물학회지 1968년 11권 3호 p.75 ~ 82
강영선, 하두봉, 안경자,
소속 상세정보
강영선 ( Kang Yung-Sun ) - 서울대학교 동물학과
하두봉 ( Ha Doo-Bong ) - 서울대학교 동물학과
안경자 ( Ahn Kyung-Ja ) - 서울대학교 동물학과

Abstract


The effects of x-irradiation on the utilization of glucose, succinate, citrate and $\\alpha$-ketoglutarate, on the response of the cell metabolism to $NaN_3$ and DNP, and on the uptake of lysine in the presence or absence of the metabolitesor the inhibitors were studied using HeLa cells and the results are summarized as follows: 1. 200r of x-irradiation had no immediate effect on the oxygen consumption of cells. 2. The oxygen consumption was greatly stimulated by succinate, $\\alpha$-ketoglutarate and citraed and in decreasing order and x-irradiation caused no remarkable change in this order. 3. The respiratory response of the cell to the metabolic inhibitors seems to be altered by x-irradiation. 4. The initial rate of the uptake of lysine was markedly retarded and the accumulation of lysine in the cell was decreased by irradiation. 5. Glucose increased the lysine uptake whereas succinate had no effect and citrate and $\\alpha$-ketoglutarate reduced the absorption. X-irradiation did not alter this tendency. 6. The inhibitory effects of $NaN_3$ and DNP on the lysine uptake were quite different from those seen in the oxygen consumption.

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