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Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease

Korean Circulation Journal 2020년 50권 5호 p.395 ~ 405
오창명 ( Oh Chang-Myung ) - Gwangju Institute of Science and Technology Department of Biomedical Science and Engineering

류동렬 ( Ryu Dong-Ryeol ) - Sungkyunkwan University School of Medicine Department of Molecular Cell Biology
조성수 ( Cho Sung-Soo ) - Dankook University College of Medicine Dankook University Hospital Department of Internal Medicine
장양수 ( Jang Yang-Soo ) - Yonsei University College of Medicine Severance Hospital Department of Internal Medicine

Abstract


Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP and mitochondrial dysfunction is the root cause for developing heart failure. Therefore, maintenance of mitochondrial quality control (MQC) is an essential process for cardiovascular homeostasis and cardiac health. In this review, we describe the major mechanisms of MQC system, such as mitochondrial unfolded protein response and mitophagy. Moreover, we describe the results of MQC failure in cardiac mitochondria. Furthermore, we discuss the prospects of 2 drug candidates, urolithin A and spermidine, for restoring mitochondrial homeostasis to treat CVD.

키워드

Mitochondrial quality control; Heart; Urolithin A; Spermidine
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