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프로톤펌프저해제 사용과 폐렴 발생의 연관성: 국민건강보험공단 표본코호트자료를 사용한 환자-대조군 연구

Association of Proton Pump Inhibitor Use and Risk Of Pneumonia: A Case-control Study Using the National Health Insurance Sample Cohort Database

약학회지 2020년 64권 2호 p.103 ~ 108
김종주, 장은진, 조준우, 손현순,
소속 상세정보
김종주 ( Kim Jong-Joo ) - CHA University Pharmaceutical Information Research Institute
장은진 ( Jang Eun-Jin ) - Andong National University College of Natural Science
조준우 ( Jo Jun-Woo ) - Kyungpook National University College of Natural Sciences
손현순 ( Sohn Hyun-Soon ) - CHA University College of Pharmacy

Abstract


Recently, the use of proton pump inhibitors in Korea has increased rapidly and the risk of pneumonia has been raised in PPI users. We aimed to investigate the association between PPI and pneumonia and to identify the risk factors. In this case-control study, we used the National Health Insurance Sample Cohort Database (2002 to 2013). Cases were defined as subjects hospitalized or visited emergency unit with pneumonia from January 2013 to December 2013, and up to four controls were matched to each case by age, gender among subjects without pneumonia. Conditional logistic regression was used to calculate the odds ratio (OR) and adjusted odds ratio (aOR) and 95% confidence intervals (CI). A total of 2,366 cases and 9,464 controls were included in this analysis. The crude odds ratio of PPI use and pneumonia was 1.15 (95% CI, 1.01-1.30), and the association for most recent use of PPI within 30 days before hospitalization with pneumonia became stronger (OR, 1.33; 95% CI, 1.04-1.70). Comorbidities adjusted odds ratio was 1.15 (95% CI, 1.01-1.32), but aOR in recent PPI users was not statistically significant (aOR, 1.18; 95% CI, 0.90-1.54). This study demonstrated that PPI use is associated with increased risk of pneumonia, but further studies reflecting patient's clinical condition and precious PPI use are necessary.

키워드

Proton pump inhibitor; pneumonia; case-control; national health insurance sample cohort database; population based

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