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Dimethylnitrosamine으로 유발된 생쥐 간섬유화에 대한 풋귤 추출물의 억제 효과

Suppressive Effects of Premature Citrus unshiu Extract on Dimethylnitrosamine-induced Hepatic Fibrosis in Mice

약학회지 2020년 64권 5호 p.377 ~ 386
한상철, 윤지현, 윤원종, 윤선아, 강희경, 유은숙,
소속 상세정보
한상철 ( Han Sang-Chul ) - Jeju National University School of Medicine Department of Medicine
윤지현 ( Yun Ji-Hyun ) - Jeju Tourism University Business Incubation Center SamWon Nature Co., Ltd.
윤원종 ( Yoon Weon-Jong ) - Jeju Technopark Jeju Biodiversity Research Institute
윤선아 ( Yoon Seon-A ) - Jeju Technopark Biodiversity Research Institute
강희경 ( Kang Hee-Kyoung ) - Jeju National University School of Medicine Department of Medicine
유은숙 ( Yoo Eun-Sook ) - Jeju National University School of Medicine Department of Medicine

Abstract


Hepatic fibrosis is a wound healing process of the liver, which is characterized by overproduction andaccumulation of extracellular matrix. Hepatic fibrosis occurs when chronic inflammation causes a deposition of scar tissue.
Dimethylnitrosamine (DMN) is a potent liver toxin that can lead to fibrosis of the liver. DMN causes massive hepatocytedamage, cell death by necrosis or apoptosis and liver tissue distribution. Citrus unshiu, which is known to contain severalflavonoids, has pharmacological effects on anti-oxidative, anti-cancer, anti-microviral and anti-inflammation activity. Therefore,we investigated the effect of premature C. unshiu and fermented premature C. unshiu extract on DMN-induced hepaticfibrosis mouse model. Here, we show that administration of premature C. unshiu and fermented premature C. unshiureduces the generation of triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde(MDA) and cytochrome P450 2E1 (CYP2E1) in mouse serum. Also, the extract reduced the mRNA expression ofglutathione S-transferases (GSTs), Heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and increasedinflammatory factors such as IL-6, COX-2 and iNOS. These results suggest that premature C. unshiu has anti-hepaticfibrosis activity by regulating metabolic detoxification pathways such as cytochrome P450s and GSTs.

키워드

hepatic fibrosis; dimethylnitrosamine; Citrus unshiu; cytochrome P450s; glutathione S-transferases

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