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The efficacy of 18F-FDG PET/CT in the preoperative evaluation of pancreatic lesions

Annals of Surgical Treatment and Research 2020년 98권 4호 p.184 ~ 189
 ( Akcam Atilgan Tolga ) - Cukurova University Faculty of Medicine Department of General Surgery

 ( Teke Zafer ) - Cukurova University Faculty of Medicine Department of Surgical Oncology
 ( Saritas Ahmet Gokhan ) - Cukurova University Faculty of Medicine Department of General Surgery
 ( Ulku Abdullah ) - Cukurova University Faculty of Medicine Department of General Surgery
 ( Guney Isa Burak ) - Cukurova University Faculty of Medicine Department of Nuclear Medicine
 ( Rencuzogullari Ahmet ) - Cukurova University Faculty of Medicine Department of General Surgery

Abstract


Purpose: Since the treatment strategy for benign and malignant pancreatic lesions differ, we aimed to evaluate the clinical value of PET/CT in the diagnosis and management of pancreatic lesions.

Methods: Ninety patients who had a histologically confirmed pancreatic lesion were studied. Receiver operating characteristic (ROC) curve analysis was used to investigate the ability of PET/CT to differentiate malignant lesions from benign tumors.

Results: The malignant and benign groups comprised 64 and 26 patients, respectively. Despite the similarity in the size of primary tumors (P = 0.588), the mean maximum standardized uptake values (SUVmax) obtained from PET/CT imaging were significantly higher in malignant lesions (9.36 ± 5.9) than those of benign tumors (1.04 ± 2.6, P < 0.001). ROC analysis showed that the optimal SUVmax cutoff value for differentiating malignant lesions (to an accuracy of 91%; 95% confidence interval, 83%?98%) from benign tumors was 3.9 (sensitivity, 92.2%; specificity, 84.6%).

Conclusion: PET/CT evaluation of pancreatic lesions confers advantages including fine assessment of malignant potential with high sensitivity and accuracy using a threshold SUVmax value of 3.9.

키워드

Chronic pancreatitis; Pancreas; Pancreatic neoplasms; Pancreatic pseudocyst; Positron emission tomography computed tomography
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