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Chronological changes in quality of life and body composition after gastrectomy for locally advanced gastric cancer

Annals of Surgical Treatment and Research 2020년 98권 5호 p.262 ~ 269
박기범, 박지연, 이승수, 정호영, 권오경,
소속 상세정보
박기범 ( Park Ki-Bum ) - Kyungpook National University Chilgok Hospital Gastric Cancer Center
박지연 ( Park Ji-Yeon ) - Kyungpook National University Chilgok Hospital Gastric Cancer Center
이승수 ( Lee Seung-Soo ) - Kyungpook National University Hospital Department of Surgery
정호영 ( Chung Ho-Young ) - Kyungpook National University School of Medicine Department of Surgery
권오경 ( Kwon Oh-Kyoung ) - Kyungpook National University Chilgok Hospital Gastric Cancer Center

Abstract


Purpose: We evaluated the changes in body composition (BC) and quality of life (QoL) in patients who underwent gastrectomy for advanced gastric cancer.

Methods: BC data using segmental multifrequency bioelectrical impedance analysis and QoL data from the EORTC (European Organisation for the Research and Treatment of Cancer) gathered via QLQ-C30 and QLQ-STO22 questionnaires were obtained from 300 patients preoperatively and at 1, 2, and 3 years after surgery. In total, 114 patients underwent total gastrectomy (TG group) and 186 underwent distal gastrectomy (DG group).

Results: According to BC analysis, at 3 years postoperatively, the average body weight (P = 0.002), protein mass (P = 0.028), body fat mass (P = 0.009), skeletal muscle mass (P = 0.037), and visceral fat area (P = 0.012) was significantly decreased in the TG group than in the DG group compared to the preoperative. In the QLQ-C30, physical functioning (P = 0.001), role functioning (P = 0.013), and fatigue (P = 0.005) showed significantly worse QoL in the TG group than in the DG group at 2 and 3 years postoperatively. In the QLQ-STO22, pain (P = 0.001), reflux symptoms (P = 0.009), eating restrictions (P = 0.001), anxiety (P = 0.008), taste (P = 0.011), and body image (P = 0.014) showed greater continuous deterioration postoperatively in the TG group than in the DG group.

Conclusion: Persistent deterioration of BC and QoL is a serious concern following total gastrectomy. Long-term management of BC is required after gastrectomy and efforts should be made to improve the QoL in patients as soon as possible, postoperatively.

키워드

Body composition; Gastrectomy; Quality of life; Stomach neoplasms

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