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Klotho as a potential predictor of deceased donor kidney transplantation outcomes

Annals of Surgical Treatment and Research 2020년 98권 6호 p.332 ~ 339
김서민, 한아람, 안상현, 민상일, 민성기, 하종원,
소속 상세정보
김서민 ( Kim Suh-Min ) - Chung-Ang University College of Medicine Department of Surgery
한아람 ( Han Ah-Ram ) - Seoul National University College of Medicine Department of Surgery
안상현 ( Ahn Sang-Hyun ) - Seoul National University College of Medicine Department of Surgery
민상일 ( Min Sang-Il ) - Seoul National University College of Medicine Department of Surgery
민성기 ( Min Seung-Kee ) - Seoul National University College of Medicine Department of Surgery
하종원 ( Ha Jong-Won ) - Seoul National University College of Medicine Department of Surgery

Abstract


Purpose: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correlation between donor Klotho expression and clinical outcomes of kidney transplantation.

Methods: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR).

Results: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m2 vs. 63.9 ± 28.2 mL/min/1.73 m2, P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m2 vs. 61.2 ± 16.5 mL/min/1.73 m2, P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho.

Conclusion: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome.

키워드

Deceased donor; Kidney transplantation; Klotho

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