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Effect of enhanced recovery after surgery protocol on recovery after open hepatectomy: a randomized clinical trial

Annals of Surgical Treatment and Research 2020년 99권 6호 p.320 ~ 328
Nakanishi Wataru, Miyagi Shigehito, Tokodai Kazuaki, Fujio Atsushi, Sasaki Kengo, Shono Yoshihiro, Unno Michiaki, Kamei Takashi,
소속 상세정보
 ( Nakanishi Wataru ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Miyagi Shigehito ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Tokodai Kazuaki ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Fujio Atsushi ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Sasaki Kengo ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Shono Yoshihiro ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Unno Michiaki ) - Tohoku University Graduate School of Medicine Department of Surgery
 ( Kamei Takashi ) - Tohoku University Graduate School of Medicine Department of Surgery

Abstract


Purpose: Enhanced recovery after surgery (ERAS) is beneficial to patients undergoing digestive surgery. However, its efficacy in patients undergoing open hepatectomy remains unclear.

Methods: Consecutive patients scheduled for open hepatectomy were randomly assigned to undergo either ERAS or conventional postoperative management. The primary endpoint was the amount of time that elapsed before patients were considered medically fit for discharge (MFD) and length of hospital stay (LOHS). Secondary endpoints included morbidity, mortality, the time to first flatus, defecation, first walk, and freedom from infusion. Perioperative serum nutritional markers, insulin resistance, respiratory quotient (RQ), and resting energy expenditure (REE) were also assessed.

Results: Between August 2014 and March 2017, 57 patients were randomized into 2 groups; ERAS group (n = 29) and conventional management (n = 28). The median MFD was not significantly different between the ERAS and conventional management groups (6.5 vs. 7 days; P = 0.381). Recovery from gastrointestinal paresis was significantly quicker in the ERAS group (1.8 vs. 2.4 days; P = 0.004). There were no significant differences in serum markers, insulin resistance, RQ, and REE.

Conclusion: This trial did not demonstrate greater efficacy of the ERAS protocol following open hepatectomy in terms of the MFD and LOHS. However, the ERAS protocol was associated with better recovery from postoperative gastrointestinal paresis, suggesting that it is useful for patients undergoing open hepatectomy.

키워드

Enhanced recovery after surgery; Hepatectomy; Perioperative treatments; Randomized controlled trial

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