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Trametes cubensis 버섯 추출물이 소의 대동맥 내피세포의 혈관 기능에 미치는 효능

Effect of Trametes cubensis Extract on Vascular Function of Bovine Aortic Endothelial Cells

한국균학회지 2020년 48권 1호 p.1 ~ 13
장수정 ( Jang Su-Jeong ) - 단국대학교 분자생물학과

이동형 ( Lee Dong-Hyeung ) - 단국대학교 미생물학과
김성환 ( Kim Seong-Hwan ) - 단국대학교 미생물학과
박현용 ( Park Heon-Yong ) - 단국대학교 분자생물학과

Abstract


Mushrooms have been extensively used as traditional medicines to treat cancer and inflammatory diseases. In this study, we examined whether Trametes cubensis extract (TCE) exerted beneficial effects on cardiovascular function. First, we demonstrated that TCE was non-cytotoxic and enhanced cell proliferation of bovine aortic endothelial cells (BAEC).
Moreover, TCE induced cell migration and blocked lipopolysaccharide-induced adhesion of monocytes to BAEC. We performed a variety of cell signaling studies, showing that TCE activates p38 MAPK and generates reactive oxygen species (ROS). Our results showed that TCE-induced vascular functions were mediated by p38 MAPK, but not by ROS. These results provide insights into bio-medical applications of TCE as a preventive or therapeutic agent for treating cardiovascular diseases including atherosclerosis.

키워드

Cell migration; Endothelial cells; Heterotypic cell adhesion; p38 MAP kinase; Trametes cubensis
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