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Four-week inhalation toxicity study of 1-propanol in F344 rats

Toxicological Research 2020년 36권 4호 p.285 ~ 292
김용순, 조은상, 박가영, 임철홍,
소속 상세정보
김용순 ( Kim Yong-Soon ) - Occupational Safety and Health Research Institute
조은상 ( Cho Eun-Sang ) - Occupational Safety and Health Research Institute
박가영 ( Park Ka-Young ) - Occupational Safety and Health Research Institute
임철홍 ( Lim Cheol-Hong ) - Occupational Safety and Health Research Institute

Abstract


1-Propanol is used as a solvent for waxes, vegetable oils, resins, cellulose esters, and ethers, and is not considered harmful to humans by food and non-occupational exposures. However, workers are potentially exposed to 1-propanol by inhalation when it is used in the workplace. Thus, inhalation toxicity data are needed to assess the hazard of 1-propanol for workers safety. Five male and five female F344 rats were exposed to 1-propanol vapor for 4-weeks (6 h/day, 5 days/week) at concentrations of 0, 100, 400, and 1600 ppm in a whole-body inhalation chamber system. The actual exposure concentrations were 100.11?±?5.10, 403.19?±?12.31, and 1598.08?±?139.58 ppm for the low, middle, and high dose groups, respectively. No clinical signs, significant mean body weight changes, significant changes of hematology or blood biochemistry results, or histopathological abnormalities were seen related to exposure to the test substance. Under the conditions of this study, the no-observed-adverse-effect level of 1-propanol was over 1600 ppm.

키워드

Inhalation toxicity; 1-Propanol; No-observed-adverse-effect level; Occupational exposure

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