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The effect of green tea catechins on breast cancer resistance protein activity and intestinal efflux of aflatoxin B1 via breast cancer resistance protein in Caco-2 cells

Toxicological Research 2020년 36권 4호 p.293 ~ 300
Tuntiteerawit Peeradon, Jarukamjorn Kanokwan, Porasuphatana Supatra,
소속 상세정보
 ( Tuntiteerawit Peeradon ) - Khon Kaen University Faculty of Pharmaceutical Sciences Graduate Program in Toxicology
 ( Jarukamjorn Kanokwan ) - Khon Kaen University Faculty of Pharmaceutical Sciences Division of Pharmaceutical Chemistry
 ( Porasuphatana Supatra ) - Khon Kaen University Faculty of Pharmaceutical Sciences Graduate Program in Toxicology

Abstract


Aflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus spp., was proved as one of the major causes of human hepatocellular carcinoma (HCC) when chronically consumed. An efflux of AFB1 was reported to be associated with breast cancer resistance protein (BCRP) whose activity could also be modulated by green tea catechins. The purpose of this study was, therefore, to examine the impacts of green tea catechins on BCRP activity in Caco-2 cells by H33342 (bis-benzamide, BCRP substrate) accumulation and AFB1 efflux. Results showed a significant decrease (p?

키워드

Mycotoxins; Transporter; Absorption; Polyphenols

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