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폴리페놀 함유 블랙 초크베리의 산화적 스트레스 및 염증에 대한 보호 효과

The protective effects of polyphenol-rich black chokeberry against oxidative stress and inflammation

한국식품과학회지 2020년 52권 2호 p.138 ~ 143
전소현 ( Jeon So-Hyeon ) - Pusan National University Department of Food Science and Nutrition

김보경 ( Kim Bo-Kyung ) - Pusan National University Department of Food Science and Nutrition

Abstract


Black chokeberry (Aronia melanocarpa) has been suggested to exert antioxidant and anti-inflammatory effects due to its high polyphenol content. However, the mechanisms underlying the effects of black chokeberry on the alterations of nuclear factor E2-related factor 2 (NRF2) and nuclear factor κB (NF-κB) in macrophages have not been thoroughly studied. In this study, we investigated the protective effects of polyphenol-rich black chokeberry extract (CBE) against lipopolysaccharide (LPS)-induced oxidative stress and inflammation in RAW 264.7 macrophages. CBE significantly attenuated the increase of cellular reactive oxygen species (ROS) levels and the nuclear translocation of NRF2 in LPSstimulated macrophages. The mRNA abundances of Nrf2 and its downstream antioxidant genes were significantly decreased in LPS-stimulated macrophages. The LPS-induced mRNA expression of proinflammatory cytokines was significantly inhibited by reducing the nuclear translocation of NF-κB by CBE. These data suggest that black chokeberry may be used for the prevention of oxidative stress and inflammation-associated disease.

키워드

Black chokeberry; Aronia melanocarpa; oxidative stress; inflammation; macrophages
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