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Resource conservation using whole body autophagy: Self-digestion of shedded gut lining cells in the small intestine

한국식품과학회지 2020년 52권 3호 p.244 ~ 248
이필준 ( Lee Phil-Jun ) - Ajou University College of Pharmacy

조남기 ( Cho Nam-Ki ) - Chonnam National University College of Pharmacy
 ( Yoo Hee-Min ) - Korea Research Institute of Standards and Science Group for Biometrology Microbiological Analysis Team
장선영 ( Chang Sun-Young ) - Ajou University College of Pharmacy
고현정 ( Ko Hyun-Jeong ) - Kangwon National University College of Pharmacy Laboratory of Immunology and Microbiology
김홍표 ( Kim Hong-Pyo ) - Ajou University School of Pharmacy

Abstract


To retain valuable resources, organisms adopt several strategies including coprophagy. Cells covering the outer skin and internal digestive lumen are actively recycled to maintain their integrity. In present study, we suggested that the small intestine can consume dead cells in a manner similar to how it consumes protein from the diet. We examined the eluates from five segments of the mouse small intestine and cecum and 2 segments of the large intestine and small intestine tissue, and detected immunoreactivity with eukaryotic caveolin-1 and β-actin antibodies only in the cecum and 2 segments from the large intestine. Bacterial agitation of the mouse intestine with Shigella disrupted the architecture and absorptive function of the small intestine. Small intestine eluates were immunoreactive with murine caveolin-1 and contained heme as determined by dot blot analysis. We concluded that the body conserves resources in the small intestine by disposing of and recycling shedded cells.

키워드

caveolin-1; small intestine; autophagy; heme; resource conservation
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