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LPS로 유도된 RAW 264.7 대식세포에서 Argyreia capitata (Vahl) Choisy 추출물의 NF-κB pathway 조절을 통한 항염증 효능 평가

Evaluation of anti-inflammatory effect by regulating NF-κB pathway of Argyreia capitata (Vahl) Choisy extract in LPS-induced RAW 264.7 macrophages

한국식품과학회지 2020년 52권 3호 p.249 ~ 254
정미라 (  ) - Kyungpook National University School of Food Science and Biotechnology

조유영 (  ) - Kyungpook National University School of Food Science and Biotechnology
 ( Bach Tran The ) - Vietnam Academy of Science and Technology Institute of Ecology and Biological Resources
엄상미 ( Eum Sang-Mi ) - Korea Research Institute of Bioscience & Biotechnology International Biological Material Research Center
정성근 ( Jung Sung-Keun ) - Kyungpook National University School of Food Science and Biotechnology

Abstract


Argyreia capitata (Vahl) Choisy is a species of the genus Argyreia. Although many studies have analyzed the biological activity of A. nervosa, A. speciasa, and A. acuta, the anti-inflammatory effect of A. capitata extract (ACE) remains unclear. In this study, we evaluated the anti-inflammatory effect of ACE using lipopolysaccharide (LPS)-induced inflammatory markers in RAW 264.7 cells. We confirmed that the ACE inhibited the LPS-induced NO (nitric oxide) and iNOS (inducible nitric oxide synthase) expression in RAW 264.7 cells. ACE suppressed not only the LPS-induced phosphorylation of IKK, IκB, and p65 but also IL-1β expression. Collectively, these results suggest that ACE is a novel anti-inflammatory agent that suppresses iNOS expression, NO production, and the NF-κB signaling pathways

키워드

Argyreia capitata (Vahl) Choisy extract (ACE); nitric oxide (NO); NF-κB (nuclear factor kappa-B); inflammatory cytokines; anti-inflammatory effect
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