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Aronia melanocarpa reduced adiposity via enhanced lipolysis in high-fat diet-induced obese mice

한국식품과학회지 2020년 52권 3호 p.255 ~ 262
김현경 ( Kim Hyun-Kyung ) - Hanyang University Department of Food and Nutrition

정지연 ( Jung Ji-Yeon ) - Hanyang University Department of Food and Nutrition
강은영 ( Kang Eun-Young ) - Hanyang University Department of Food and Nutrition
강경옥 ( Gang Gyoung-Ok ) - Texas A&M University Department of Animal Science
김우기 ( Kim Woo-Ki ) - Kyung Hee University Department of Food Science and Biotechnology
고광웅 ( Go Gwang-Woong ) - Hanyang University Department of Food and Nutrition

Abstract


Obesity is a critical health issue in Korea, where half of all adults are overweight and a third obese. Aronia melanocarpa -rich in flavonoids and phenolics- with antioxidant and anti-inflammatory activities, could have anti-obesity activity and reduce body fat mass by upregulating lipolysis and β-oxidation in obese mice. Male C57BL/6J mice (n=12) were assigned into four groups: normal chow (18% kcal from fat); high-fat diet control (HFD, 45% kcal from fat); HFD +A. melanocarpa (200 mg/kg diet); HFD+Xenical (500 mg/kg diet, positive control). Antioxidant capacity of A. melanocarpa was established in vitro and in vivo. Weight loss was induced as decreased adiposity and lowered respiratory quotient at rest suggested oxidation of stored fat. Adiposity reduction, accompanied with elevated fat utilization, was owing to enhanced activity of hormone-sensitive lipase. Thus, A. melanocarpa lowered adiposity by enhancing lipolysis and utilization of fatty acids in visceral fat.

키워드

anti-obesity therapeutic; Aronia melanocarpa; hormone-sensitive lipase; lipolysis; respiratory quotient
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