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미토콘드리아 활성화를 통한 양파(Allium Cepa L.) 과육 및 과피의 Amyloid-β 유도성 인지손상에 대한 개선효과

Ameliorative effect of onion (Allium Cepa L.) flesh and peel on amyloid-β-induced cognitive dysfunction via mitochondrial activation

한국식품과학회지 2020년 52권 3호 p.263 ~ 273
박선경 ( Park Seon-Kyeong ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science

 ( Lee Uk ) - National Institute of Forest Science Division of Special Forest Products
강진용 ( Kang Jin-Yong ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
김종만 ( Kim Jong-Min ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
신은진 ( Shin Eun-Jin ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
허호진 ( Heo Ho-Jin ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science

Abstract


In this study, in order to confirm the ameliorative effects of onion (Allium cepa L.) flesh and peel on amyloidbeta (Aβ)-induced cognitive dysfunction, we evaluated their in vitro neuroprotection and in vivo cognitive functions. As the result of in vitroneuroprotection, the protective effect of the ethyl acetate fraction of onion flesh (EOF) on Aβ-induced cytotoxicity was similar to that of the ethyl acetate fraction of onion peel (EOP). In the behavioral tests, the EOF and EOP effectively improved the Aβ-induced learning and memory impairments. For this reason, it could be concluded that the EOF and EOP improved the antioxidant activities (superoxide dismutase, oxidized glutathione/total glutathione, and malondialdehyde) in brain tissue. In addition, the EOF and EOP effectively activated mitochondrial functions by protecting the mitochondrial membrane potential, ATP, mitochondria-mediated protein (BAX and cytochrome c), and caspase 3/7 activities. The EOF and EOP also improved the cholinergic system (acetylcholinesterase and acetylcholine). Therefore, we suggest that onion could be used for management of Aβ-induced cognitive dysfunction.

키워드

Allium cepa L.; amyloid-β; cognition; cholinergic system; mitochondrial function
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