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국내산 초피와 산초의 산업적 활용 가능성: 고당으로 유도된 뇌신경세포 독성에 대한 추출물의 보호 효과

Industrial potential of domestic Zanthoxylum piperitum and Zanthoxylum schinifolium: Protective effect of both extracts on high glucose-induced neurotoxicity

한국식품과학회지 2020년 52권 3호 p.274 ~ 283
한혜주, 박선경, 김민지, 안준우, 이세진, 강진용, 김종만, 허호진,
소속 상세정보
한혜주 ( Han Hye-Ju ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
박선경 ( Park Seon-Kyeong ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
김민지 ( Kim Min-Ji ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
안준우 ( An Jun-Woo ) - Gyeongsang National University Institute of Agriculture and Life Science Department of Food Science and Technology
이세진 ( Lee Se-Jin ) - Gyeongsang National University Institute of Agriculture and Life Science Department of Food Science and Technology
강진용 ( Kang Jin-Yong ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
김종만 ( Kim Jong-Min ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science
허호진 ( Heo Ho-Jin ) - Gyeongsang National University Institute of Agriculture and Life Science Division of Applied Life Science

Abstract


This study focused on the in vitro investigation of antioxidant and anti-diabetic activities, along with neuroprotection against high glucose-induced cytotoxicity, in order to evaluate the physiological effects of Zanthoxylum piperitum and Zanthoxylum schinifolium. The highest total phenolic content was measured in the 40% ethanolic extracts of Zanthoxylum piperitum (EZP) and Zanthoxylum schinifolium (EZS). The in vitro EZP antioxidant activity showed a relatively higher ABTS/DPPH radical scavenging activity and malondialdehyde inhibitory effect than that of EZS. The EZP inhibited carbohydrate hydrolysis (α-glucosidase and α-amylase) more efficiently than EZS in anti-diabetic tests. However, EZS showed a more efficient inhibition of advanced glycation end-products formation than EZP. In addition, both EZP and EZS effectively protected human-derived neuronal cells from high glucose-induced cytotoxicity. Finally, the physiological compounds were analyzed using UPLC IMS-QTOF/MSE, and the main EZP (quercetin-3-O-glucoside and 3-caffeoylquinic acid) and EZS (5-caffeoylquinic acid) compounds were identified as phenolic compounds.

키워드

diabetes; high glucose; neuroprotection; Zanthoxylum piperitum; Zanthoxylum schinifolium

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