잠시만 기다려 주세요. 로딩중입니다.

Alternative chromatographic method for the assay test of terbutaline and salbutamol using ionic liquid assisted aqueous mobile phase

분석과학 2020년 33권 4호 p.169 ~ 176
Mai Xuan-Lan, 최유성, Truong Quoc-Ky, Truong Quoc-Ky, Nguyen Thi-Ngoc-Van, 한상범, 김경호,
소속 상세정보
 ( Mai Xuan-Lan ) - Kangwon National University College of Pharmacy
최유성 ( Choi Yu-Sung ) - Kangwon National University College of Pharmacy
 ( Truong Quoc-Ky ) - Kangwon National University College of Pharmacy
 ( Truong Quoc-Ky ) - University of Medicine Pham Ngoc Thach Faculty of Pharmacy
 ( Nguyen Thi-Ngoc-Van ) - Can Tho University of Medicine and Pharmacy Pharmacy Faculty
한상범 ( Han Sang-Beom ) - Chung-Ang University College of Pharmacy
김경호 ( Kim Kyeong-Ho ) - Kangwon National University College of Pharmacy

Abstract


Separation of basic compounds using reverse phase chromatography on a silica-based stationary phase represents a major challenge, because of the interaction between the cationic sites of the basic compounds with the anionic silanols of the stationary phase. This study presents a simple, reliable, and organic solvent - free liquid chromatographic method for the determination of terbutaline and salbutamol, in which a room temperature ionic liquid (RTIL) is used as mobile phase additive. We investigated various mobile phase parameters affecting the retention of the two compounds, such as types and concentration of RTILs and, pH of the mobile phase were investigated. The developed method was validated according to International Conference on Harmonization (ICH) guidelines and successfully applied effectively to determine salbutamol sulfate in pharmaceutical preparations.

키워드

ionic liquid; salbutamol; terbutaline; reverse phase HPLC

원문 및 링크아웃 정보

등재저널 정보