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Anti-inflammatory Effect of Water-soluble Chitosan Oligosaccharideson Human Monocyte THP-1 Cells

한국키틴키토산학회지 2020년 25권 3호 p.143 ~ 147
Nguyen Que Thanh Thanh, Hoang Thi Xoan, 박제권, 김재영,
소속 상세정보
 ( Nguyen Que Thanh Thanh ) - Gachon University Department of Life Science
 ( Hoang Thi Xoan ) - Gachon University Department of Life Science
박제권 ( Park Jae-Kweon ) - Gachon University Department of Life Science
김재영 ( Kim Jae-Young ) - Gachon University Department of Life Science

Abstract


The various functional properties of chitosan have been investigated for use in biomedical applications. Indeed, chitosan or its derivatives have shown anti-inflammatory effect by regulating a range of cytokines, chemokines or growth factors. In the present study, we prepared water-soluble chitosan oligosaccharide (AS-WSC) by the hydrolysis of high molecular weight water-soluble chitosan (HMW-WSC) and examined its anti-inflammatory effect on LPS-stimulated human monocytic THP-1 cells. Our results revealed that LPS-induced NF-κB activity of THP-1 cells was significantly suppressed by treatment with 0.02% AS-WSC. In addition, 0.02% AS-WSC treatment down-regulated the expression of Toll-like receptor 4 and inflammatory cytokines, such as IL-1β and TNF-α, but had no effect on IL-10 and IL-4 expression in LPS-stimulated THP-1 cells. Our results suggest that 0.02% AS-WSC can be considered as a promising anti-inflammatory agent.

키워드

Chitosan; Anti-inflammation; Monocyte; Toll-like receptor 4; NF-kappaB; Cytokines

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