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Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes

Molecules and Cells 2020년 43권 9호 p.763 ~ 773
송예찬, 이승언, Jin Young, 박현우, 전경희, 이한웅,
소속 상세정보
송예찬 ( Song Yae-Chan ) - Yonsei University College of Life Science and Biotechnology Department of Biochemistry
이승언 ( Lee Seung-Eon ) - Yonsei University College of Life Science and Biotechnology Department of Biochemistry
 ( Jin Young ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
박현우 ( Park Hyun-Woo ) - Yonsei University College of Life Science and Biotechnology Department of Biochemistry
전경희 ( Chun Kyung-Hee ) - Yonsei University College of Medicine Department of Biochemistry and Molecular Biology
이한웅 ( Lee Han-Woong ) - Yonsei University College of Life Science and Biotechnology Department of Biochemistry

Abstract


Recently, tumor microenvironment (TME) and its stromal constituents have provided profound insights into understanding alterations in tumor behavior. After each identification regarding the unique roles of TME compartments, non-malignant stromal cells are found to provide a sufficient tumorigenic niche for cancer cells. Of these TME constituents, adipocytes represent a dynamic population mediating endocrine effects to facilitate the crosstalk between cancer cells and distant organs, as well as the interplay with nearby tumor cells. To date, the prevalence of obesity has emphasized the significance of metabolic homeostasis along with adipose tissue (AT) inflammation, cancer incidence, and multiple pathological disorders. In this review, we summarized distinct characteristics of hypertrophic adipocytes and cancer to highlight the importance of an individual’s metabolic health during cancer therapy. As AT undergoes inflammatory alterations inducing tissue remodeling, immune cell infiltration, and vascularization, these features directly influence the TME by favoring tumor progression. A comparison between inflammatory AT and progressing cancer could potentially provide crucial insights into delineating the complex communication network between uncontrolled hyperplastic tumors and their microenvironmental components. In turn, the comparison will unravel the underlying properties of dynamic tumor behavior, advocating possible therapeutic targets within TME constituents.

키워드

adipose tissue; cancer-associated adipocyte; inflammation; obesity; tumor microenvironment

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