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WNT Signaling in Lung Repair and Regeneration

Molecules and Cells 2020년 43권 9호 p.774 ~ 783
Raslan Ahmed A., Yoon Jeong-Kyo,
소속 상세정보
 ( Raslan Ahmed A. ) - Soonchunhyang University Soonchunhyang Institute of Medi-Bio Science
 ( Yoon Jeong-Kyo ) - Soonchunhyang University Soonchunhyang Institute of Medi-Bio Science

Abstract


The lung has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionally distinct epithelial cell populations with specific functions are generated from several different types of stem/progenitor cells localized within four histologically distinguished regions: trachea, bronchi, bronchioles, and alveoli. WNT signaling is one of the key signaling pathways involved in regulating many types of stem/progenitor cells in various organs. In addition to its developmental role in the embryonic and fetal lung, WNT signaling is critical for lung homeostasis and regeneration. In this minireview, we summarize and discuss recent advances in the understanding of the role of WNT signaling in lung regeneration with an emphasis on stem/progenitor cells.

키워드

β-catenin; lung homeostasis; lung regeneration; lung stem/progenitor cells; WNT signaling

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