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Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients

Biomolecules & Therapeutics 2020년 28권 6호 p.491 ~ 502
김선영, 송혜경, Lee Suk-Kyeong, 김상건, 우현구, 양지은, 노현진, 김유선, Moon A-Ree,
소속 상세정보
김선영 ( Kim Sun-Young ) - Duksung Women’s University College of Natural Science Department of Chemistry
송혜경 ( Song Hye-Kyung ) - Duksung Women’s University College of Natural Science Department of Chemistry
 ( Lee Suk-Kyeong ) - Catholic University College of Medicine Department of Biomedicine and Health Sciences
김상건 ( Kim Sang-Geon ) - Dongguk University College of Pharmacy
우현구 ( Woo Hyun-Goo ) - Ajou University School of Medicine Department of Physiology
양지은 ( Yang Ji-Eun ) - Ajou University School of Medicine Department of Physiology
노현진 ( Noh Hyun-Jin ) - Ajou University School of Medicine Department of Biochemistry
김유선 ( Kim You-Sun ) - Ajou University School of Medicine Department of Biochemistry
 ( Moon A-Ree ) - Duksung Women’s University College of Pharmacy

Abstract


Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the sexes. The mortality and survival rates of many cancers, especially liver cancer, differ between men and women. Due to the pronounced sex/gender disparity, considering sex/ gender may be necessary for the diagnosis and treatment of liver cancer. By analyzing research articles through a PubMed literature search, the present review identified 12 genes which showed practical relevance to cancer and sex disparities. Among the 12 sex-specific genes, 7 genes (BAP1, CTNNB1, FOXA1, GSTO1, GSTP1, IL6, and SRPK1) showed sex-biased function in liver cancer. Here we summarized previous findings of cancer molecular signature including our own analysis, and showed that sexbiased molecular signature CTNNB1High, IL6High, RHOAHigh and GLIPR1Low may serve as a female-specific index for prediction and evaluation of OS in liver cancer patients. This review suggests a potential implication of sex-biased molecular signature in liver cancer, providing a useful information on diagnosis and prediction of disease progression based on gender.

키워드

Liver cancer; Sex/gender; Overall survival; Gene expression; Molecular signature

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