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Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Biomolecules & Therapeutics 2020년 28권 6호 p.537 ~ 541
강지수, 이주현, 임동순,
소속 상세정보
강지수 ( Kang Ji-Soo ) - Pusan National University College of Pharmacy Laboratory of Pharmacology
이주현 ( Lee Ju-Hyun ) - Kyung Hee University College of Pharmacy Laboratory of Pharmacology
임동순 ( Im Dong-Soon ) - Pusan National University College of Pharmacy Laboratory of Pharmacology

Abstract


Sphingosine-1-phosphate (S1P) and its receptors have been implicated in atopic dermatitis. S1P2 was found to function as a proallergic receptor, while its antagonist JTE-013 was found to suppress allergic asthma in mice. Topical application of JTE-013 has not been investigated in an in vivo model of atopic dermatitis. Therefore, the therapeutic potential of JTE-013 topical application was evaluated by the use of a 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis mouse model. DNCB-induced inflammation and mast cell accumulation in skin tissues were significantly suppressed by topical JTE-013 treatment in BALB/c mice. DNCB-induced increase of lymph nodes sizes and elevated inflammatory cytokines (IL-4, IL-13, IL-17, and IFN-γ) in lymph nodes were also significantly reduced by the JTE-013 treatment. Elevated serum levels of IgE were significantly suppressed by the topical treatment of JTE-013. In summary, the topical treatment of JTE-013 S1P2 antagonist suppressed DNCB-induced atopic dermatitis symptoms and immune responses. These results suggested JTE-013 as a potential therapeutic agent for atopic dermatitis.

키워드

Atopy; Dermatitis; Dendritic cell; Sphingosine 1-phosphate; S1P2

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